Main hub. I suggest setting a bookmark to this page.      RELOAD/REFRESH FROM TIME TO TIME!!
Underlined text is generally hot-linked (mostly blue; some blue text in internal pages is not underlined and not hotlinked)

Glossary of terms used in Population Genetics  

  Download "WebSoftware.doc" list of software resources for pop. gen. and some phylogenetics

Go to web page outlining major aspects of analyzing genetic population structure (WAAP.html)
   (some important measures to calculate, very basic intro. to the practicalities of running a few of the many software choices)

     Jump to navigation help note

            Jump to reading list and syllabus                      Go to Dave McDonald's home page

Lecture Notes

Go to Lecture 1      (Mon 25-Aug-08, Wed 27-Aug, Fr 29-Aug)  [Intro. to course -- topics covered, essentials of DNA as a genetic marker]
Go to Lecture 2          (Fr-29-Aug-08 to Fr 5-Sep)                         [Overview of phylogenetics]
Go to Practicum # 1   (Fr 5-Sep)                                                    [Tree-building with PHYLIP ]

Go to Lecture 2a   (Wed 10-Sep)   [Speciation and hybridization]
Practicum 2           (Fr 12-Sep)       [Tree-building with PAUP -- no web notes]

Go to Lecture 3     (Mon 15-Sep & Fr 19-Sep)   [Population Genetics I -- Intro., Hardy-Weinberg]

Go to Lecture 4     (Mon 22-Sep)   [Population Genetics II -- Heterozygosity, H_E or D; intro. to F_ST]
Go to Lecture 5     (Fr 26-Sep & Weds. 1-Oct)       [Population Genetics III -- Wahlund effect, isolate breaking, PHSC approach to F_ST]
Practicum 3           (Fr 26-Sep)       [More FStat software exercises; see data and instruction file in WyoWeb folder under "Practica"]
             or  Download it from here (guide to using Exel add-in Microsatellite Toolkit and program FStat on campus computers)

Practicum 4            (Fr 3-Oct)       [Interpretation of FStat software output; Assignment tests]
               Go to the Assignment overview web page

Go to Lecture 6     (Wed 8-Oct)       [Population Genetics IV -- Genetic distances: Cavalli-Sforza chord, Nei's, Reynolds' ]
Go to Lecture 7      (Tu 10-Oct)        [Population Genetics V -- N_e, effective population size; overview of alternative markers]

           Go to web page describing how to calculate F_ST from heterozygosities (FST.html).

Lecture 7a.  (Fr 17-Oct)   Go to web page outlining major aspects of analyzing genetic population structure (WAAP.html)
   (some important measures to calculate, very basic intro. to the practicalities of running a few of the many software choices)

Go to Lecture 8      (Wed 22-Oct)         [Population Genetics VI -- intro. to microsatellites as a genetic marker]

Mon 27-Oct Case history: AFLP and mtDNA analyses of hybridization in native fish (Powerpoint available on WyoWeb)

Go to Lecture 9                                  [Population Genetics VII -- Microsatellite analyses of black bear genetic structure]

Week of 3 to 7-Nov.  Lectures and practicum on using the software Structure. 
    See WyoWeb folders (Practicum 6 folder, HW4 folder and Software guide folder)
     Download Word document  on using Structure 

Go to Lecture 11    (Wed 19-Nov)      [Conservation genetics]

Go to Lecture 12    (Wed 3-Dec)         [Highlights of the course]

Lecture notes beyond this point have not yet been revised for 2008 

Lecture notes are under construction (and some links may not yet work). Beyond the red text are lectures from previous years, subject to extensive revision, and placed here in case you want to get a feel for future topics.

Homework pages

Download Word document  PHYLIPinfo.doc      Download Word document  on using Structure

Download Excel sheet of worked example of UPGMA, Neighbor-joining and Fitch-Margoliash tree from great ape 5-taxon distance matrix

Download Word doc. of steps for UPGMA & NJ            

For full list of references (~ 1,400 references, many with abstracts), e-mail me and I will send you a Word attachment or transfer it to a flash drive you bring to my office or to class.

Download Syllabus (excluding calendar page and reading list)      

         Download "WebSoftware.doc" list of software resources

        Glossary of terms used for Genetic/Molecular Markers

 Download Excel spreadsheet guide (Hexp.XL) to calculating expected heterozygosity, H_exp (or as Bruce Weir prefers to call it, Gene Diversity, D)       

Dr. David McDonald    BioSciences 413       dbmcd@uwyo.edu     766-3012
Office hours W 11-12, Th 10:00-12:00 or by appointment

A note on navigating the web pages:
Figures, Equations and Required Readings are labeled in a "chapter-like" manner, with each lecture as the equivalent of a chapter.  That is, Lecture 1's web page will be "Chapter 1".  All Figures in that web page will be numbered Fig. 1.1, 1.2, ...1.n for the n Figures it includes.  The same will be true for Equations (numbers for which will be toward the right-hand margin).  I will try to hotlink most references to Figures or Equations WITHIN a web page, but may not do so BETWEEN web pages.  That is, a reference to Eqn 1.1 in the 2nd web page ("Chapter 2") might require you to jot that number down and surf back later.  The hotlinks will be the standard underline format.  I will have links between all the web pages that I design for this course.  I may even put in some external links. Come see me if you need help on browsing the web pages.  Please let us know, also, if you find typos, pages that won't print properly, or other glitches.
Reading numbers may change if the lecture schedule shifts -- the updated list of number will be reposted occasionally both on the web and in the WyoWeb folders.